During the reappraisal process, the Working Group identified 2 genes, KCNE1 and KCNE2, as having numerous reports supporting their role in the etiology of drug or electrolyte-provoked LQTS, referred to as acquired LQTS (aLQTS), in addition to being reported as causes of congenital LQTS. Here, KCNE1 is linked to familial long QT syndrome.