Over 3 decades later, in 1995, the first genes thought to underlie the pathophysiology of LQTS were discovered by Mark Keating’s research team.4,5 Their identification of rare genetic variants in the KCNH2-encoded Kv11.1 potassium channel and the SCN5A-encoded Nav1.5 sodium channel in families with LQTS was revolutionary in our understanding of not only this condition but also all inherited arrhythmia syndromes. This evidence concerns the gene KCNA3 and familial long QT syndrome.