KCNE2 and familial long QT syndrome: Although KCNE2 was concluded to have strong evidence for aLQTS, a recent comprehensive review of reported KCNE2 variants reported for LQTS demonstrated that KCNE2 variants routinely require secondary provocation to induce phenotype, persuading the Working Group to conclude that KCNE2 has no supportive evidence as a cause of LQTS in the absence of provoking factors.31