PIP and breast cancer: A variety of reports have described more accurate diagnosis of micrometastasis in axillary lymph nodes, by using reverse transcription of some indicators such as prolactin-induced protein, CK19, mammaglobin, carcinoembryonic acid, and MUC1. Among these makers, CK19 and mammaglobin have illustrated high sensitivity and specificity for the detection of lymph node metastasis of breast cancer[25].