VEGFA and breast cancer: Among them, –2578C>A (rs699947), –634G>C (rs2010963), –460C>T (rs833061), and +936C>T (rs3025039) were demonstrated to regulate VEGF expression (Ruiz et al., 2012; Chung and Chanock, 2011) VEGFA SNPs were shown to affect VEGFA levels in different cell models, (Watson et al., 2000) including breast cancer (Krippl et al., 2003).