VEGFA and breast cancer: During the past 2 decades, Bevacizumab, an agent recognizing and blocking the pathway of VEGF-A, has shown some efficacy in combination regimens to improving progression-free survival and overall survival of some solid malignancies, such as breast cancer, renal cell carcinoma, and non-small-cell lung cancer (NSCLC) (Welch et al., 2010).