In this regard, there is clear evidence to support that both autocrine and paracrine mechanisms of IL-6 and IL-8 production have a correlation with the promotion of MM cell growth, survival, and migration, and angiogenesis in the BM- microenvironment (Zhu et al., 2003; Ndlovu et al., 2009). The gene discussed is IL6; the disease is Miyoshi myopathy.