CDK4 and cancer: This present study shows that aurisin A has promise as an anti-cancer agent, as evidenced by; i) inhibited cell proliferation and cancer cell migration (decreased EGFR and pp38 expression), ii) induced apoptosis (up-regulated caspase-3) and iii) cell cycle arrest at the G0/G1 phase with decreased expression of the proteins cyclin D and Cdk-4.