While the HFD-fed mice in our studies gained significantly more weight than those fed the ND [Fig. S4(A) in the Supplementary Material], and the tumor weights in HFD-fed mice were significantly larger than those from ND-fed mice [Fig. S4(B) in the Supplementary Material], the tumors appeared similar for the different diet-treatment groups using H&E staining [Figs. S4(C)–S4(D) in the Supplementary Material], as well as the expression of positive cancer-associated fibroblasts via immunohistochemical α-SMA staining [Figs. S4(E) and S4(F) in the Supplementary Material]. The gene discussed is ACTA1; the disease is cancer.