PRF1 and neoplasm: CD8‐positive T cells recognize tumour cell antigens and drive anti‐tumour response by secreting effector cytokines, releasing cytotoxic molecules such as granzyme B and perforin, and inducing apoptosis in tumour cells.30 The CXCL9‐11/CXCR3 axis regulates CD8‐positive T cell migration, differentiation and activation.16, 31 CD8‐positive T cells express CXCR3 and are capable of invading into tumours when activated by chemokines.