In conclusion, we have demonstrated that high expression of 32 chemokines and receptors (CCL2, 4‐5, 7‐8, CCL22‐25, CCR1‐9, CXCL2‐3, 5, 9‐13, 16, XCL1‐2 and XCR1) in SKCM regional LN tissue is associated with a good prognosis, which may be related to the attraction of immune cells to the TME and elimination of tumour cells. This evidence concerns the gene XCR1 and neoplasm.