There were differences between the IDH mutated and IDH wild-type gliomas with respect to the SGZ, both when measured from tumor center (p < 0.001, median distance 35.7 mm vs 20.8 mm) and tumor border (p = 0.006, median distance 7.7 mm vs 0 mm) (Fig. 2d). Here, IDH2 is linked to central nervous system cancer.