NEB and autosomal recessive nemaline myopathy: Its critical role in muscle function became apparent when mutations in NEB were associated with autosomal recessive nemaline myopathy, a disease characterised by generalised skeletal muscle weakness and the presence of electron dense protein accumulations (nemaline rods) on patient muscle biopsy examination (after TPM3, NEB was the second gene associated with this condition) (Pelin et al. 1999).