To associate physiologic relevance of anti-tumor activity and the suppressive effect of Vδ2+ T cells ex vivo, we first exposed untouched Vδ2+ T cells to BTN3A1-expressing tumor cells (U251 or SK-Mel-28, Fig. 4b) and consecutively co-cultured them with autologous αβ T cells. The gene discussed is BTN3A1; the disease is neoplasm.