Our findings are consistent with extensive studies showing cognitive and pathological benefits from enhancing either ACE2 activity or boosting the levels of Ang-(1–7) in mouse models of stroke (reviewed in [65]), chronic cerebral hypoperfusion [66], diabetes [67] and in recent mouse models of AD where compounds were infused intracerebroventricularly [68, 69]. Here, ACE2 is linked to Alzheimer disease.