MAS1L and Alzheimer disease: Our findings, together with recent data from postmortem brain tissue, reaffirm the importance of the angiotensin hypothesis in AD and indicate that activation of the regulatory ACE2/Ang-(1–7)/MasR rRAS pathway, which works to downregulate the cRAS pathway whilst directly boosting memory and learning, provides an exciting, alternative and novel therapeutic target for potential treatment in AD.