To understand the mechanism underlying the cell cycle arrest of gastric cancer cells induced by knocking down AURKB, we next examined the effect of AURKB on various key cell cycle regulatory molecules, including CCND1, CDC16, CDC6, CDC26, CCNB2, CCNF, p27 and E2F1, in gastric cancer cells [16]. The gene discussed is CCND1; the disease is gastric cancer.