demonstrated that UCA1 enhances GC cell metastasis by regulating the stability of GRK2 protein via promoting Cbl-c-mediated ubiquitination and degradation of GRK2, in addition to activating the extracellular signal-regulated kinase (ERK)-matrix metallopeptidase-9 (MMP-9) signaling pathway. The gene discussed is GRK2; the disease is gastric cancer.