TP53 and neoplasm: TP53 mutations are associated with tumor development, and some result in p53 loss and gain of function and have a dominant-negative effect, which affects cell survival (Ano Bom et al., 2012, Ghosh et al., 2017, Lasagna-Reeves et al., 2013, Xu et al., 2011, Yang-Hartwich et al., 2015, Zhu et al., 2015).