Furthermore, different aggregation phenotypes were observed in biopsies of breast tumor (Levy et al., 2011) and cell lines of different cancers, including breast (Ano Bom et al., 2012), ovarian (Yang-Hartwich et al., 2015), and prostate cancers (Kluth et al., 2014), supporting the hypothesis that p53 undergoes misfolding prior to amyloid aggregation in these cells. This evidence concerns the gene TP53 and cancer.