TP53 and glioblastoma: Here, we explored questions related to the chemoresistance phenotype involving p53 in glioblastoma with the following aims: (1) identify p53 amyloid oligomers in glioblastoma cells, (2) investigate the composition and distribution of chemoresistant mutant p53 oligomers in living cells, (3) determine whether misfolding is a prerequisite for aggregation in cells, and (4) determine the mechanism by which mutant p53 amyloid aggregation occurs in solution.