In addition, other potential risk factors associated with QTc interval prolongation such as hypothermia (Rai et al., 2014), hypokalemia (Weiss et al., 2017), glucose levels/hypoglycemia (Sertbas et al., 2017), metabolites active on hERG, accumulation of test article in the myocardium, and/or inhibition of the translocation/trafficking of the hERG channel to the membrane (Eckhardt et al., 2005) will not be evaluated in silico unless this is known a priori and is integrated into the model. The gene discussed is KCNH2; the disease is Hypokalemia.