Consistently, human AD brains show misregulations in canonical cell cycle driving proteins (e.g., CDC25 phosphatases) and inhibitory proteins (e.g., wee1 kinase) in the direction toward mitosis; in degenerating neurons, Cdc25A and Cdc25B show higher activity, while Wee1 shows lower activity (Ding et al., 2000; Tomashevski, Husseman, Jin, Nochlin, & Vincent, 2001; Vincent et al., 2001). Here, WEE1 is linked to Alzheimer disease.