EDN1 and glomerulosclerosis: The overexpression of EDN1 associated with pathological kidney phenotypes, such as age‐dependent development of renal cysts, interstitial fibrosis of the kidneys, and glomerulosclerosis, and leads to a progressive decrease in glomerular filtration rate.9 Fang Yang et al5 genotyped three SNPs in EDN1 and discovered the association of rs5370 with the clinical phenotype in CPNS.