Endothelin‐1 encodes a preproprotein, which associated with pathological kidney phenotypes, such as age‐dependent development of renal cysts, interstitial fibrosis of the kidneys, and glomerulosclerosis, and leads to a progressive decrease in glomerular filtration rate.9 The association of EDN1 rs5370 G > T gene polymorphism revealed the potential relationship between EDN1 gene polymorphism and the pathogenesis of CPNS. This evidence concerns the gene EDN1 and cystic kidney disease.