The overexpression of EDN1 associated with pathological kidney phenotypes, such as age‐dependent development of renal cysts, interstitial fibrosis of the kidneys, and glomerulosclerosis, and leads to a progressive decrease in glomerular filtration rate.9 Fang Yang et al5 genotyped three SNPs in EDN1 and discovered the association of rs5370 with the clinical phenotype in CPNS. The gene discussed is EDN1; the disease is cystic kidney disease.