With this regard, we also demonstrated that other viral agents influence the CXCL10 concentration in KTRs, and especially HCMV DNAemia showed a strong cumulative effect on CXCL10 blood but not urine levels, an observation that is in line with recent findings that CXCL10 in blood but not in urine increased in KTRs with histologically verified HCMV infection 33. This evidence concerns the gene CXCL10 and cytomegalovirus infection.