In this study, we longitudinally analyzed CXCL10 in KTRs during different stages of BKPyV replication and demonstrate that, along with progression of BKPyV replication, CXCL10 in blood and urine gradually increases, from viral DNAuria over low‐ and high‐level DNAemia to a decrease of renal function and histological evidence PVAN. Here, CXCL10 is linked to BK-virus nephropathy.