For instance, MALAT1, which is an lncRNA, directly interacts with DBC1 and P53 and regulates the acetylation of P53 protein.31 Here, we demonstrated that AFDN‐DT also interacts with core histone proteins and directly binds to the transcriptional regulatory regions of the genes essential for malignant transformation, such as FOS, JUN and EGR1, which encode three of the most widely known transcriptional factors in cancer. The gene discussed is TP53; the disease is cancer.