The FOS and JUN belong to the AP‐1 transcriptional complex and have been reported to regulate the malignant transformation in GC.32, 33 We found that the AFDN‐DT overexpression down‐regulated the expression of FOS and JUN, indicating that AFDN‐DT directly inhibits the oncogenes in GC, and this further validates its tumour suppressive function. The gene discussed is JUN; the disease is neoplasm.