KMT2A and neoplasm: AFDN divergent transcript (AFDN‐DT), also known as MLLT4 antisense RNA 1 (MLLT4‐AS1), is an lncRNA located upstream of the Afadin (AFDN) gene.20 AFDN, otherwise known as MLLT4 and AF6, has been identified as a fusion partner in Lysine Methyltransferase 2A gene (KMT2A).21 In our previous study, we showed that high levels of AFDN‐DT, but not AFDN, correlated with a favourable outcome in patients with GC20 and suggested that AFDN‐DT might be tumour suppressor, even though the mechanism of AFDN‐DT in GC remains completely unknown.