In the early stage in syphilis, there were more specimens with detection of anti‐TP IgM than those with detection of anti‐TP IgG.9 On the other hand, it has been reported that TpN47 is highly reactive in the early stage of syphilis or in patients with a previous infection.6, 12 It is possible that Lumi‐TP might detect anti‐TP antibodies in the infectious early stage. This evidence concerns the gene CD40LG and syphilis.