Lefevre and colleagues showed that for the detection of anti‐TP antibody for each stage of syphilis, anti‐TP IgM was positive for 16/17 cases of primary syphilis, 11/13 of secondary syphilis, 9/14 of early latent syphilis, and 0/33 of late latent syphilis. This evidence concerns the gene CD40LG and syphilis.