In our cohort of 130 consecutive cases of advanced HGSC, higher expression of intra-epithelial lymphocytes (CD3), PD-1 (in lymphocytes), and PD-L1 (in macrophages) was a predictor of better outcome with similar hazards of death, even after adjusting for age at diagnosis, stage, and residual tumor after primary surgery. Here, CD274 is linked to neoplasm.