CCN5 and cancer: Several reports have suggested a role of hypoxia in modulating cancer cell migration and invasion; knockdown of Wnt-1 induced signaling protein 2 (WISP-2) in non-invasive MCF7 cells enhanced their motility under hypoxic conditions (0.2% O2, 24 h)65 as did treatment of MCF-7 with CoCl2 (200 μM, 24 h)63 and MDA-MB-231 with DFO (30–300 μM, 24 h).