Furthermore, pull-down of the AMPylated proteins from neuroblastoma cells under FICD E234G OX conditions revealed a general increase in AMPylation including proteins such as CTSB, TPP1, CAPZB, and NSFL1C, which were found AMPylated in COs (Supplementary Fig. 25, Supplementary Data 11). The gene discussed is CTSB; the disease is neuroblastoma.