To determine if the absence of a Muc2 mucus layer was predisposing Muc2−/− for increase risk for LPS-induced sepsis, persistent low-grade colitis that caused alterations/depletion of the mucus layer was induced in Muc2+/+ littermates by treating with 0.75% DSS for 3 weeks. Here, MUC2 is linked to Sepsis.