These findings, coupled with the low expression of PD-L1 and PD-L2 in tumor cells (Supplementary Fig. 9a, b), may in part explain the ineffectiveness of CTLA4 and PD1 blockade in metastatic UM1 and suggest a potential role for LAG3 in T cell exhaustion in UM. This evidence concerns the gene LAG3 and neoplasm.