The decrease of nuclear YAP due to cytoplasmic co-segregation with Aβ was confirmed in cortical neurons of 5xFAD mice (Supplementary Fig. 11a, b) and human mutant APP-KI mice (Supplementary Fig. 11c, d) at 3 months, prior to the onset of cognitive impairment. The gene discussed is APP; the disease is Cognitive impairment.