TAL1 and acute lymphoblastic leukemia: The mice transplanted with cells expressing TAL1 SE-targeting sgRNAs (sgMut2 and sgWT2) also displayed more severe leukemic phenotypes compared to the nontargeting sgGal4, resulting in increased infiltration of T-ALL leukemic cells in peripheral blood (PB) and bone marrow (BM) by flow cytometry and bloodsmear analyses (Fig. 4k, l).