PDE6C and Blindness: We tested our single-AAV vector platform in Gnat1IRD2/IRD2/Pde6ccpfl1/cpfl1 mice; the Gnat1 and Pde6c defects in these mice cause blindness due to a functional lack of rods and cones15, leaving behind only a residual cortical light response to brightest flashes16 mediated by Gnat217.