Co-inoculation of MC38Cd73KO with MSCs greatly accelerated tumor progression with a marked increase in CAF (α-SMA+) abundancy (Fig. 8d, e, Supplementary Fig. 8g, h), which marginally impacted TIL-CD8 cells (Fig. 8g, Supplementary Fig. 8g, h). The gene discussed is CD8A; the disease is neoplasm.