In EG7-bearing mice, A2A antagonist ZM241385, A2B antagonist PSB1115, or CD73-neutralization individually resulted in a similar modest but statistically significant suppression of EG7 tumor progression (Fig. 6a, b) with marked increases in total TIL-CD8 cells and IFN-γ-producing CTLs compared to those in iso-type control-treated mice (Fig. 6c). The gene discussed is CD8A; the disease is neoplasm.