MAPT and Mental deterioration: The fact that plaques in Trem2-deficient mice are more injurious to adjacent neurites but show weaker labeling with molecular probes (Thioflavin S, methoxy-X04 and X-34) related to those used in the clinic (11C-PiB, 18F-Florbetapir) helps explain why cognitive decline correlates better with tau pathology and synapse loss than with brain amyloid detection.