Finally, when we combined SKI606 with SAC alleviation in the CIN cell line HT29, in which MT polymerization rates cannot further be increased (Fig 5F [Ertych et al, 2014]), we found that SKI606-imposed Src inhibition was no longer acting synergistically with SAC alleviation in reducing cell numbers (Fig S5D), further indicating that altered MT dynamics is underlying the synergy observed between SKI606 and SAC inhibition. Here, SRC is linked to cervical squamous intraepithelial neoplasia.