MAD2L1 and cancer: Although SAC impairment is rare in human cancer (Gordon et al, 2012), many cancers show signs of a partially impaired SAC, for instance, as a result of increased expression of proteins with a direct role in the SAC or their regulators, such as Rb mutations that lead to increased expression of Mad2, and thus, provoke a CIN phenotype (Pfau & Amon, 2012).