This loss of the RHOGEF/DBL and PH domains is also observed in the p190 form of BCR–ABL (m-bcr; minor bcr) in CML which has been hypothesized to lead to a B-cell lineage blast phase (Montenegro-Garreaud et al. 2017). The gene discussed is MCF2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.