There has been a handful of cases of CD25 deficiency in humans often manifesting in an IPEX-like syndrome.67–69 A notable case which presented with autoimmune enteropathy at 6 months had Foxp3+ Tregs with defective IL-10 expression suggesting that IL-2 responsiveness is important for Treg-mediated IL-10 production. The gene discussed is IL10; the disease is autoimmune enteropathy.