The absence of changes in different markers of T lymphocytes (CD4 and CD8) and their associated proinflammatory cytokines and chemokines (i.e., IFN-γ, IL-17, IL-12, IL-23) [13, 79–83] in the brain of MSA mice compared to wildtype animals suggest that these cells are not critical in the neuroinflammatory process observed in PLP-hαSyn mice. Here, CD4 is linked to multiple system atrophy.