Synucleinopathies such as Parkinson’s disease (PD) and multiple system atrophy (MSA) constitute neurodegenerative disorders characterized by autonomic failure, motor impairment and the abnormal accumulation of α-synuclein (α-syn) in the cytoplasm of either neurons (Lewy bodies, characteristics of PD) or in oligodendroglial cytoplasmic inclusions (GCIs, characteristics of MSA) [20–23]. The gene discussed is SNCA; the disease is Parkinson disease.