In particular, we identified two genes, 3-hydroxy-methyl-glutaryl CoA synthase 2 (HMGCS2) and aldo-ketoreductase 1C3 (AKR1C3), which were significantly upregulated in PCa cells upon co-culture with CAFs and which were also significantly elevated in human PCa specimens compared to benign tissue. Here, HMGCS2 is linked to posterior cortical atrophy.