Therefore, tumor cells mainly downregulate the expression of MICA/MICB on the surface while upregulating the expression of hypoxia inducible factor 1α (HIF 1α) to increase the cell surface expression of disintegrin and metalloproteinase containing domain protein 10 (ADAM10), which can cleave surface MICA/MICB [84, 85]. This evidence concerns the gene ADAM10 and neoplasm.