We also observed a decrease in Olig2 expression level at all ages in Tg2576 compared to Wt, suggesting a defect in the key molecular signaling involved in OPC differentiation in AD mice, indeed the expression of the MBP, the main myelin protein, is lower in the Tg2576 group than the Wt group at most ages. This evidence concerns the gene OLIG2 and Alzheimer disease.