In addition, HGF and TNF-stimulated gene (TSG)-6 from MSCs have been shown to ameliorate inflammation in albumin-induced CKD model via the down-regulation of IL-6, IL-8, TNF-α, CCL-2, and CCL-5, which was partly mediated by the regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling [9]. This evidence concerns the gene TNF and chronic kidney disease.