In the Caucasian population, no significant association was found between both the IL-1RN and IL-1beta genes and the risk of BC within them, except for the 511 C/T polymorphisms in the interleukin 1 beta (IL1B) promoter region polymorphism, which was related to the tumor stage and lymph node involvement phenotypes [29]. The gene discussed is IL1B; the disease is breast cancer.