Additionally, SR141716 upregulated the expression of natural killer group 2D (NKG2D) ligands (MHC class I chain-related protein A MICA and MHC class I chain-related protein B MICB) on the surface of glioma cells via signal transducer and activator of transcription 3 (STAT3) inactivation leading to a consequent increase of MICA/B levels and enhancing the recognition of glioma cells by NK-cells. This evidence concerns the gene KLRK1 and central nervous system cancer.