The cannabinoid Δ9-THC disrupted HER2–CB2R complexes by selectively binding to CB2R, which led to the inactivation and degradation of HER2 through disruption of HER2–HER2 homodimers promoting antitumoral responses both in vitro and in vivo, which may constitute a new strategy to treat HER2+ breast tumors [84]. Here, ERBB2 is linked to breast neoplasm.