CSF2 and neoplasm: Additionally, CBD modulated the breast tumor microenvironment through a decrease of the cytokines production, as chemokine (C-C motif) ligand 3 (CCL3) and granulocyte-macrophage colony-stimulating factor (GM-CSF), which determined a reduction of the recruitment of total macrophages and an M2 macrophages polarization into the primary and secondary tumor sites, encouraging the tumor progression and metastasis to distant organs [76].