CNR1 and neoplasm: Similar results were obtained with the synthetic cannabinoids JWH-015 and WIN-55,212-2, CB2 and CB1/CB2 agonists, respectively, that from 0.1 to 2 μM significantly inhibited EGF- or serum-induced proliferation and were also able to confer rounded cellular shape, thus inhibiting migration and invasion of NSCLC cell lines and tumor growth and dissemination in murine models.