Similar results were obtained with the synthetic cannabinoids JWH-015 and WIN-55,212-2, CB2 and CB1/CB2 agonists, respectively, that from 0.1 to 2 μM significantly inhibited EGF- or serum-induced proliferation and were also able to confer rounded cellular shape, thus inhibiting migration and invasion of NSCLC cell lines and tumor growth and dissemination in murine models. The gene discussed is CNR1; the disease is non-small cell lung carcinoma.