MMP2 and breast cancer: In breast cancer cells, 2-methyl-2′-F-anandamide (Met-F-AEA) inhibits Wnt/β-catenin pathway through a reduction of β-catenin nuclear translocation and transcriptional activity, which culminates with a downregulation of β-catenin target genes, such MMP2, c-Myc, and cyclin D. The inhibition of the Wnt pathway was accompanied by a reduction of mesenchymal markers (e.g., vimentin, N-cadherin, Snail, and Slug) [11] (Figure 1).