UGT2B4 and cancer: As canagliflozin is metabolized and excreted by UGT1A9 and UDP glucuronosyltransferase family 2 member B4 (UGT2B4), we speculate that cancer cells expressing SGLT2 combined with low levels of UGT1A9 and UGT2B4, will make these tumor cells sensitive to canagliflozin.