Of these, eight proteins, glypican 3 (GPC3), squamous cell carcinoma antigen (SCCA), haptoglobin, C3 precursor, seprase, hemoglobin subunit gamma, hemoglobin subunit alpha, and teneurin-3, showed higher relative peaks in HCC cases with normal AFP levels than the liver cirrhosis controls. This evidence concerns the gene TENM3 and cirrhosis of liver.