As shown in Table 3, the sensitivity and specificity of each protein for diagnosing HCC were as follows: GPC3 (61.9%, 100%), SCCA (95.2%, 50%), haptoglobin (85.7%, 60%), C3 (76.2%, 70%) Trim22 (90%, 85.7%), seprase (76.2%, 90%) Hb-γ (66.7%, 80%), Hb-α (66.7%, 100%), BMP1 (95.2%, 71.4%), and teneurin-3 (95.2%, 80%), respectively. The gene discussed is C3; the disease is hepatocellular carcinoma.