Detection was highest in meningioma (59%) and glioblastoma (50%); single nucleotide variants were detected in 61 genes (most frequent in TP53 (n = 79), followed by Janus kinase 2 (JAK2, n = 10), neurofibromatosis type 1 (NF1, n = 7), EGFR (n = 7), proto-oncogene B-Raf (BRAF, n = 6), IDH1 (n = 5), neuroblastoma RAS viral oncogene homolog (NRAS, n = 5), guanine nucleotide-binding protein (G protein), alpha-stimulating activity polypeptide 1 (GNAS, n = 5), and ataxia-telangiectasia mutated gene (ATM, n = 4). The gene discussed is EGFR; the disease is glioblastoma.