ATG2B and cancer: Furthermore, miRNA-143 has been found to target autophagy-related 2B in non-small cell lung cancer H1299 cells, and as higher sensitivity to 5-FU is observed when the autophagic response is attenuated in A549 cells, it would be likely that changes in autophagy pathways contributes to the enhanced chemosensitivity However, evidence of its role in chemosensitivity appears cancer or strand dependent, as miRNA-143-3p was found to be increased not decreased in exosomes of gemcitabine-resistant NSCLC cells.