TP53 and primary cutaneous T-cell non-Hodgkin lymphoma: Elevated miRNA-122 levels may promote resistance to treatment in cutaneous T-cell lymphoma (CTCL), as miRNA-122 mimics were shown to promote resistance to γ-secretase inhibitors (GSIs), and the proteasome inhibitors bortezomib and MG132 in these diseases, via inhibition of p53 and activation of Akt [134].