Serum levels of miRNA-143 in bladder cancer correlate with clinical stage, lymph node metastasis, distant metastasis, and prognosis Despite high levels of miRNA-143 correlating with poor progression-free survival in aggressive bladder cancer [174] this miRNA has been shown to enhance sensitivity to gemcitabine in 5637 cells; this was proposed to be via repression of IGF-1R signaling Further to this, in vitro experiments which induced FOXD2-AS1 knockdown, a long non-coding RNA which can inhibit miRNA-143, enhanced sensitivity to gemcitabine [175]. This evidence concerns the gene FOXD2 and metastatic malignant neoplasm in the lymph nodes.