Early studies showed that GLA could be a dietary supplement to ameliorate dry skin and AD by modifying FAs metabolism and improving SCPB, however, more recent meta-analyses and reviews raised doubts about earlier findings and the effectiveness of GLA-rich supplementation (mostly EPO, borage oil that contains three times more GLA than EPO) in the therapeutic management of AD [22,90,91,92]. Here, EPO is linked to Alzheimer disease.