The latter has been confirmed by both increased infiltration of the perifollicular and papillary dermis by CD3+ and CD4+ T cells in uninvolved skin in acne patients and the effectiveness of the anti-inflammatory agents, such as topical benzoyl peroxide, dapsone, and antibiotics, in reducing non-inflammatory lesions (i.e., comedones) in acne patients [155]. Here, CD4 is linked to acne.