FFAR4 and inflammatory bowel disease: Results of Mobraten et al., who examined the LC-PUFAs in the treatment of inflammatory bowel disease (IBD), showed that both ω-3 (EPA, DHA) and ω-6 PUFAs (ARA), natural GPR120 ligands, induce the same GPR120-mediated anti-inflammatory signaling events, but with different kinetics and efficiency in intestinal epithelial Caco-2 cells [50].