Several studies presented data on a significant association, in CLL patients, between AIC or other autoimmune disorders and unfavorable prognostic parameters, particularly high lymphocyte count, high β2 microglobulin level, and increased expressions of CD38 and ZAP-70 [15,16,18,21,22,56]. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.