Importantly, the mutant allele G is significantly implicated among the haplotype definitions, implying that a change from an A to G as in the CD209 (rs4804803) gene polymorphism will hamper downstream expression of the gene, thereby affecting the immune response and contributing to malaria pathogenesis, which was not seen in the STAT6 (rs3024974) polymorphism. This evidence concerns the gene CD209 and malaria.