Over time, biomarkers have been developed and used in the evaluation of sepsis, such as interleukins (IL)-1, -2, -4, -6, -8, -12, complement components C3a and C5a, C-reactive protein (CRP), procalcitonin (PCT), etc. [227,228], but it’s been proven that their individual deficiencies, sometimes to the point of inaccuracy, can be overcome when using combinations of these markers [229]. The gene discussed is CRP; the disease is Sepsis.