NPs were conceived in order to: (i) Transport the hydrophobic DTX in the inner poly (D,L-lactide-co-glycolide) (PLGA) core; (ii) favor electrostatic association of the amphiphilic PS to a positively charged polyethyleneimine (PEI) layer covering the core; (iii) exploit active targeting, via the HA receptor CD44 over-expressed on cancer cells, covering the NP surface with a layer of HA [19]; (iv) guarantee synergic interaction of the transported drugs through the easy modification of drug ratio inside NPs [20]. Here, CD44 is linked to cancer.