PTEN and familial pancreatic carcinoma: In contrast, PLK1 mRNA levels in a high PTEN-expressing group have been significantly down-regulated when compared with the low PTEN group in PTEN-expressing PACA-AU (TNM:T = 3, Grade = 2) and GSE21501 data sets, which had a favorable prognosis of pancreatic cancer patients to elevated PTEN expression (Figure 6d).